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Cool subcellular snapshots 📸 SLAC scientists have developed a better method for preparing thin cell slices. This paves the way for imaging tiny structures inside cells via cryo-electron tomography (which involves shooting electrons through thin slices of frozen samples) that were previously off-limits. The team used a tri-coincident system, which aligns the focal planes of three instruments: a scanning electron microscope, an ion beam, and an optical microscope. To test out the approach, they i
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What's cryo-EM? Cryogenic electron microscopy (cryo-EM) is a revolutionary tool for studying the molecular architectures of proteins, viruses, cells and the specialized molecular machines within cells. To learn more about how cryo-EM works, from preparing samples to capturing atomic images and using them to help create treatments for disease. | SLAC National Accelerator Laboratory
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