Proteoforms, the diverse molecular variants of proteins, are key to understanding cellular functions, disease mechanisms, and biomarker discovery in proteomics.

Protein AMPylation represents a specialised post‐translational modification (PTM) in which an adenosine monophosphate (AMP) moiety is covalently attached to specific amino acid residues on target ...

In the intricate regulation of inflammation, metabolic reprogramming and posttranslational modification (PTM) have emerged as pivotal players, offering new avenues for understanding the fine-tuned ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Exploring the post-translational modifications of a key protein in Parkinson's disease, researchers uncover potential pathways for future therapies in neurodegenerative diseases in general.

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...

Paired Box 3 (PAX3) is a protein that plays a critical role in the formation of tissues and organs during embryonic development and can positively (and less frequently, negatively) regulate gene ...

Non-CHO cell expression systems gain traction as faster, more flexible alternatives for biologics manufacturing.

Built on groundbreaking research from Israel ’s Weizmann Institute of Science, Promise Bio developed the first cloud-based platform for broad epiproteomics, helping researchers uncover disease ...

Neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, present a significant health challenge, affecting over 50 million people globally. One common feature of these diseases is the ...